The role of Th1 and Th2 cytokines among women with recurrent spontaneous miscarriage
نویسندگان
چکیده
The objective of this study was to compare the concentrations of Th1 (IFN-γ , TNF-α) and Th2 (IL-4,IL-10) cytokines in the serum of normal pregnant and recurrent spontaneous abortion (RSA) women in 1st trimester as well as in the normal fertile non pregnant women. In RSA women there was a significant increasing in the mean concentration of Th1 cytokines (TNFα and IFNγ) as well as in Th1/TH2 than normal pregnant and non pregnant women. In normal pregnant women there was significant increasing in the mean concentration of Th2 cytokines (IL-4 and IL-10). RSA was associated with increasing concentration of Th1 cytokines while successful pregnancy was associated with increase concentration of Th2 cytokines in the first trimester of pregnancy, indicating Th2 bias in normal pregnancy and a Th1 –bias in unexplained RSA. © 2014 Sjournals. All rights reserved.
منابع مشابه
بررسی سایتوکاینهای سلولهای Th1 و TH17 تحریک شده در محیط کشت سلولی در زنان مبتلا به سقط مکررخود به خودی
Introduction: Various immunological abnormalities have been reported in women with RSA of unknown aetiologies including autoimmune abnormalities and increased cellular immunity such as elevated natural killer (NK) , Th1 and Th17 cell levels. Th17 and Th1 cells play a central role during inflammation. Th1 cells product cytokines IFN-γ, IL-2 and Th17 cells mainly cytokines IL-17A, F, IL-22. The a...
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